Vitamin D deficiency is associated with poor outcomes and increased mortality in severely ill patientsY Arnson et al. QJM. 2012 Jul. Show
AbstractBackground: Vitamin D plays a seminal role in many homeostatic mechanisms. In this study, we assessed the correlation between circulating vitamin D levels and mortality rates in critically ill patients. Methods: All patients admitted to the intensive care units (ICUs) and internal medicine wards in a university-based hospital that required mechanical ventilation were admitted. Data collected included the underlying disease, basic hematological and biochemical blood test results, APACHE II scores and serum 25-hydroxyvitamin D [25(OH)D] levels. The primary end point was defined as all-cause mortality within 60 days from admission or from acute deterioration. Results: Between December 2008 and June 2009, 130 patients were enrolled. Average vitamin D concentration was 14.04 ± 6.9 ng/ml; 107 patients were vitamin D deficient (< 20 ng/ml). Total mortality rate after 60 days was 44.3%. Vitamin D levels were correlated with white blood cell (WBC) count, but with no other measured variable. Among the deceased patients, survival curves indicated that survival of patients with vitamin D deficiency was significantly shorter than those whose vitamin D concentration was >20 ng/ml (P < 0.05); the average survival time was 15.3 ± 12.4 days for vitamin D deficient patients compared with 24.2 ± 16.5 days among those with normal vitamin D levels. Conclusion: This study demonstrated that low vitamin D levels are common among patients admitted to ICU. We observed longer survival times among vitamin D sufficient patients. Our results indicate that vitamin D concentration may be either a biomarker of survival or a co-factor. We recommend assessing the effects of vitamin D supplementation in critically ill patients. Similar articles
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What vitamin deficiency can cause low white blood count?WBCs are an important part of your immune system. They help your body fight off diseases and infections. If you have too few WBCs, you have a condition known as leukopenia.. vitamin B12.. folate.. copper.. What vitamin lowers white blood cells?To lower your high white blood cell count, you should include the following in your diet: Vitamin C. Eating Vitamin C will help regulate the levels of white blood cells in your body. Fruits like lemons, oranges, and lime are rich in vitamin C, and so are papayas, berries, guavas, and pineapples.
What is the most common reason for low white blood cell count?A low white blood cell count usually is caused by: Viral infections that temporarily disrupt the work of bone marrow. Certain disorders present at birth (congenital) that involve diminished bone marrow function. Cancer or other diseases that damage bone marrow.
Can lack of vitamin D cause low white blood cell count?Vitamin D deficiency does not have significant effect on RBC count and indices, on WBC total and differential count, nor on BP and HR.
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